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Article

Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-β deposition in Alzheimer's disease.

Alzheimer's research & therapy - 3 Nov 2021

Park Young Ho, Pyun Jung-Min, Hodges Angela, Jang Jae-Won, Bice Paula J, Kim SangYun, Saykin Andrew J, Nho Kwangsik

Abstract excerpt

BACKGROUND: The interaction between the brain and periphery might play a crucial role in the development of Alzheimer's disease (AD). METHODS: Using blood transcriptomic profile data from two independent AD cohorts, we performed expression quantitative trait locus (cis-eQTL) analysis of 29 significant genetic loci from a recent large-scale genome-wide association study to investigate the effects of the AD genetic...

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Identifiers

PMID: 34732252
DOI: 10.1186/s13195-021-00919-z
PMCID: PMC8567578

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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