Article

Transcriptome-wide association study of Alzheimer disease reveals many differentially expressed genes and multiple biological pathways in brain tissue from African American donors

2024-11-04

Abstract excerpt

<h4>Background</h4> The genetic basis of Alzheimer disease (AD) in African American (AA) individuals is much less well understood than in European-ancestry (EA) individuals. Furthermore, relatively few AA donors have been included in postmortem AD studies. <h4>Methods</h4> We generated transcriptome-wide bulk-level gene expression data derived from pre-frontal cortex (PFC) tissue obtained from 179 AA brain donors...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 76e3644e-4a15-5e81-8016-b1407e367396
DOI: 10.1101/2024.10.29.24316311

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptome-wide association study of Alzheimer disease reveals many differentially expressed genes and multiple biological pathways in brain tissue from African American donorsDOI 10.1101/2024.10.29.24316311Read

Novel differentially expressed genes and multiple biological pathways for Alzheimer's disease identified in brain tissue from African American donors.Semantic proximity Read

Identification of common molecular biomarker signatures in blood and brain of Alzheimer’s diseaseSemantic proximity Read

Blood Genome-Wide Transcriptional Profiles Reflect Broad Molecular Impairments and Strong Blood-Brain Links in Alzheimer's DiseaseSemantic proximity Read

Associations of Alzheimer’s disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegenerationSemantic proximity Read

Exploratory Single-Cell RNA Sequencing of Peripheral Blood Identifies Candidate Signatures Associated with Alzheimer’s DiseaseSemantic proximity Read

Brain Region-Dependent Alternative Splicing of Alzheimer Disease (AD)-Risk Genes Is Associated With Neuropathological Features in ADSemantic proximity Read

Differentially expressed genes in Alzheimer’s disease highlighting the roles of microglia genes including OLR1 and astrocyte gene CDK2AP1Semantic proximity Read

Using blood transcriptome analysis for Alzheimer's disease diagnosis and patient stratificationSemantic proximity Read

Targeted Sequencing of Alzheimer Disease Genes in African Americans Implicates Novel Risk VariantsSemantic proximity Read

Transcriptome Signatures for Cognitive Resilience Among Individuals with Pathologically Confirmed Alzheimer DiseaseSemantic proximity Read

Toward an Alzheimer's disease diagnosis via high‐resolution blood gene expressionSemantic proximity Read

Comparing Alzheimer's genes in African, European, and Amerindian induced pluripotent stem cell–derived microgliaSemantic proximity Read