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Article

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.

Nature neuroscience - 1 Sept 2014

De Jager Philip L, Srivastava Gyan, Lunnon Katie, Burgess Jeremy, Schalkwyk Leonard C, Yu Lei, Eaton Matthew L, Keenan Brendan T, Ernst Jason, McCabe Cristin, Tang Anna, Raj Towfique, Replogle Joseph, Brodeur Wendy, Gabriel Stacey, Chai High S, Younkin Curtis, Younkin Steven G, Zou Fanggeng, Szyf Moshe, Epstein Charles B, Schneider Julie A, Bernstein Bradley E, Meissner Alex, Ertekin-Taner Nilufer, Chibnik Lori B, Kellis Manolis, Mill Jonathan, Bennett David A

Abstract excerpt

We used a collection of 708 prospectively collected autopsied brains to assess the methylation state of the brain's DNA in relation to Alzheimer's disease (AD). We found that the level of methylation at 71 of the 415,848 interrogated CpGs was significantly associated with the burden of AD pathology, including CpGs in the ABCA7 and BIN1 regions, which harbor known AD susceptibility variants. We validated 11 of the...

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Source

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Identifiers

PMID: 25129075
DOI: 10.1038/nn.3786
PMCID: PMC4292795

Genes

ANK1
BIN1
RHBDF2
ABCA7
CDH23
RPL13
SERPINF1
SERPINF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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