Article
Genome-wide association studies of Alzheimer's disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans.
Alzheimer's research & therapy - 24 Jul 2025
Sherva Richard, Zhu Congcong, Zhang Rui, Mez Jesse, Hauger Richard, Merritt Victoria C, Panizzon Matthew, Gaziano J Michael, Catanzaro Vidriana, Schellenberg Gerard D, Pericak-Vance Margaret, Haines Jonathan L, Wang Li-San, Mayeux Richard, Farrer Lindsay A, Logue Mark W
Abstract excerpt
BACKGROUND: Alzheimer's disease (AD) risk variants have been identified in European ancestry cohorts that have stronger effects at certain ages, in individuals with a specific sex, or in those with specific isoforms of APOE, the strongest AD risk locus. However, sample sizes in African ancestry (AA) cohorts have been underpowered to perform stratified analyses. METHODS: We generated genome-wide association study...
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