Article
The fork protection complex promotes parental histone recycling and epigenetic memory.
Cell - 5 Sept 2024
Charlton Sebastian Jespersen, Flury Valentin, Kanoh Yutaka, Genzor Aitana Victoria, Kollenstart Leonie, Ao Wantong, Brøgger Peter, Weisser Melanie Bianca, Adamus Marek, Alcaraz Nicolas, Delvaux de Fenffe Charlotte M, Mattiroli Francesca, Montoya Guillermo, Masai Hisao, Groth Anja, Thon Geneviève
Abstract excerpt
The inheritance of parental histones across the replication fork is thought to mediate epigenetic memory. Here, we reveal that fission yeast Mrc1 (CLASPIN in humans) binds H3-H4 tetramers and operates as a central coordinator of symmetric parental histone inheritance. Mrc1 mutants in a key connector domain disrupted segregation of parental histones to the lagging strand comparable to Mcm2 histone-binding mutants....
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