Article
Spt6 prevents transcription-coupled loss of posttranslationally modified histone H3.
Scientific reports - 1 Jan 2013
Kato Hiroaki, Okazaki Kosuke, Iida Tetsushi, Nakayama Jun-Ichi, Murakami Yota, Urano Takeshi
Abstract excerpt
The tail of histone H3 is an ideal medium for storing epigenetic information because displacement of histone H3 is heavily restricted during transcription. To maintain the locus-specific modifications of histone H3, histone molecules should be retained locally at the original position through multiple rounds of transcription. Here, we found that fission yeast Spt6, a highly conserved RNA polymerase II-interacting...
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