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Article

The Histone Chaperones FACT and Spt6 Restrict H2A.Z from Intragenic Locations.

Molecular cell - 18 Jun 2015

Jeronimo Célia, Watanabe Shinya, Kaplan Craig D, Peterson Craig L, Robert François

Abstract excerpt

H2A.Z is a highly conserved histone variant involved in several key nuclear processes. It is incorporated into promoters by SWR-C-related chromatin remodeling complexes, but whether it is also actively excluded from non-promoter regions is not clear. Here we provide genomic and biochemical evidence that the RNA polymerase II (RNA Pol II) elongation-associated histone chaperones FACT and Spt6 both contribute to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25959393
DOI: 10.1016/j.molcel.2015.03.030
PMCID: PMC4475440

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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The Histone Chaperones FACT and Spt6 Restrict H2A.Z from Intragenic Locations.PMID 25959393Read ↗

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Spt6 prevents transcription-coupled loss of posttranslationally modified histone H3.Semantic proximity Read ↗

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FACT and the reorganized nucleosome.Semantic proximity Read ↗

Integrated molecular mechanism directing nucleosome reorganization by human FACT.Semantic proximity Read ↗

A highly conserved region within H2B is important for FACT to act on nucleosomes.Semantic proximity Read ↗

The essential histone variant H2A.Z regulates the equilibrium between different chromatin conformational states.Semantic proximity Read ↗

Histone variants and transcription regulation.Semantic proximity Read ↗

The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states.Semantic proximity Read ↗

Histone variants on the move: substrates for chromatin dynamics.Semantic proximity Read ↗

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