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Article

The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts.

Genes & development - 1 Apr 2014

Herrera-Moyano Emilia, Mergui Xénia, García-Rubio María L, Barroso Sonia, Aguilera Andrés

Abstract excerpt

FACT (facilitates chromatin transcription) is a chromatin-reorganizing complex that swaps nucleosomes around the RNA polymerase during transcription elongation and has a role in replication that is not fully understood yet. Here we show that recombination factors are required for the survival of...

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Identifiers

PMID: 24636987
DOI: 10.1101/gad.234070.113
PMCID: PMC4015491

Genes

RNH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24636987-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts.PMID 24636987Read ↗

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RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability.Semantic proximity Read ↗

Histone chaperone FACT action during transcription through chromatin by RNA polymerase II.Semantic proximity Read ↗

The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states.Semantic proximity Read ↗

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