Article
The fitness cost of rifampicin resistance in Pseudomonas aeruginosa depends on demand for RNA polymerase.
Genetics - 1 Mar 2011
Hall Alex R, Iles James C, MacLean R Craig
Abstract excerpt
Bacterial resistance to antibiotics usually incurs a fitness cost in the absence of selecting drugs, and this cost of resistance plays a key role in the spread of antibiotic resistance in pathogen populations. Costs of resistance have been shown to vary with environmental conditions, but the caus...
Topics
- Anti-Bacterial Agents
- DNA Gyrase
- DNA-Directed RNA Polymerases
- Drug Resistance, Bacterial
- Genetic Fitness
- Mutation
- Penicillin-Binding Proteins
- Pseudomonas aeruginosa
- Rifampin