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Article

Pervasive genotype-by-environment interactions shape the fitness effects of antibiotic resistance mutations.

Proceedings. Biological sciences - 30 Aug 2023

Soley Jake K, Jago Matthew, Walsh Calum J, Khomarbaghi Zahra, Howden Benjamin P, Lagator Mato

Abstract excerpt

The fitness effects of antibiotic resistance mutations are a major driver of resistance evolution. While the nutrient environment affects bacterial fitness, experimental studies of resistance typically measure fitness of mutants in a single environment only. We explored how the nutrient environment affected the fitness effects of rifampicin-resistant rpoB mutations in Escherichia coli under several conditions...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 37583318
DOI: 10.1098/rspb.2023.1030
PMCID: PMC10427823

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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