Pervasive genotype-by-environment interactions shape the fitness effects of antibiotic resistance mutations.

doi:10.1098/rspb.2023.1030

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Article

Pervasive genotype-by-environment interactions shape the fitness effects of antibiotic resistance mutations.

Proceedings. Biological sciences - 30 Aug 2023

Soley Jake K, Jago Matthew, Walsh Calum J, Khomarbaghi Zahra, Howden Benjamin P, Lagator Mato

Abstract excerpt

The fitness effects of antibiotic resistance mutations are a major driver of resistance evolution. While the nutrient environment affects bacterial fitness, experimental studies of resistance typically measure fitness of mutants in a single environment only. We explored how the nutrient environme...

Topics

Gene-Environment Interaction
Drug Resistance, Bacterial
Anti-Bacterial Agents
Mutation
Genotype
Escherichia coli
Genetic Fitness

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