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Article

DNase hypersensitive sites and association with multiple sclerosis.

Human molecular genetics - 15 Feb 2014

Disanto Giulio, Kjetil Sandve Geir, Ricigliano Vito A G, Pakpoor Julia, Berlanga-Taylor Antonio J, Handel Adam E, Kuhle Jens, Holden Lars, Watson Corey T, Giovannoni Gavin, Handunnetthi Lahiru, Ramagopalan Sreeram V

Abstract excerpt

Genome-wide association studies (GWASs) have shown that approximately 60 genetic variants influence the risk of developing multiple sclerosis (MS). Our aim was to identify the cell types in which these variants are active. We used available data on MS-associated single nucleotide polymorphisms (SNPs) and deoxyribonuclease I hypersensitive sites (DHSs) from 112 different cell types. Genomic intervals were tested...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24092328
DOI: 10.1093/hmg/ddt489

Genes

CARD11
CHST12
FCRL2
NFKBIZ
NPAS1
SOCS1
SYK
TCF7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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