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Article

Transcriptomic effects of rs4845604, an IBD and allergy-associated RORC variant, in stimulated ex vivo CD4+ T cells.

PloS one - 1 Jan 2021

Wilson Paul A, Santos Franco Sara, He Liu, Galwey Nicholas W, Meakin Jackie, McIntyre Rebecca, McHugh Simon M, Nolan Michael A, Spain Sarah L, Carlson Thaddeus, Lobera Mercedes, Rubio Justin P, Davis Bill, McCarthy Linda C

Abstract excerpt

RORγt is an isoform of RORC, preferentially expressed in Th17 cells, that functions as a critical regulator of type 3 immunity. As murine Th17-driven inflammatory disease models were greatly diminished in RORC knock-out mice, this receptor was prioritised as an attractive therapeutic target for the treatment of several autoimmune diseases. Human genetic studies indicate a significant contributory role for RORC in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34673799
DOI: 10.1371/journal.pone.0258316
PMCID: PMC8530322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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