Article
Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.
The Journal of clinical investigation - 1 Jun 2014
Kofler David M, Marson Alexander, Dominguez-Villar Margarita, Xiao Sheng, Kuchroo Vijay K, Hafler David A
Abstract excerpt
Prostaglandin E2 (PGE2) promotes Th17 expansion while otherwise inhibiting other CD4+ T cell subsets. Here, we identified a PGE2-dependent pathway that induces pathogenic Th17 cells in autoimmune disease and is regulated by the transcription factor RORC. Compared with other CD4+ cell types from healthy subjects, there is a surprising lack of the prostaglandin receptor EP2 on Th17 cells; therefore, we examined the...
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