Article

Single cell analysis of human CD8 <sup>+</sup> T cells reveals CD45RC <sup>low/-</sup> TNFR2 <sup>+</sup> CD29 <sup>low</sup> CD8 <sup>+</sup> Tregs with superior activity

2023-12-14

Abstract excerpt

<h4>ABSTRACT</h4> Although described in the 70’s, CD8 + regulatory T cells (Tregs) remain incompletely understood and to date, although several markers are used to define them, they remain poorly defined. The identification of reliable and consistent markers, as it was done for CD4 + Tregs, remains an urgent task and a challenge to advance our understanding. Herein, we analyzed total CD8 + T cells using single...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 149bd0a7-16bc-553b-a6dd-75cb288f3ae2
DOI: 10.1101/2023.12.13.571475

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single cell analysis of human CD8 <sup>+</sup> T cells reveals CD45RC <sup>low/-</sup> TNFR2 <sup>+</sup> CD29 <sup>low</sup> CD8 <sup>+</sup> Tregs with superior activityDOI 10.1101/2023.12.13.571475Read

Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysisSemantic proximity Read

Human regulatory T-cells locally differentiate and are functionally heterogeneous within the inflamed arthritic jointSemantic proximity Read

CD8+ Tregs revisited: A heterogeneous population with different phenotypes and properties.Semantic proximity Read

Future prospects for CD8+ regulatory T cells in immune toleranceSemantic proximity Read

Beyond FOXP3: a 20-year journey unravelling human regulatory T-cell heterogeneity.Semantic proximity Read

TNFR2 costimulation differentially impacts regulatory and conventional CD4 <sup>+</sup> T-cell metabolismSemantic proximity Read

Gene expression-based identification of antigen-responsive CD8 <sup>+</sup> T cells on a single-cell levelSemantic proximity Read

Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR.Semantic proximity Read

Single-Cell RNA-Seq Analysis Uncovers Distinct Functional Human NKT Cell Sub-Populations in Peripheral BloodSemantic proximity Read

Single-cell and multi-omic characterization of ex vivo expanded ASTRLs from stable kidney transplant recipients reveals a regulatory T cell phenotype.Semantic proximity Read

Transcriptomic profiling of human effector and regulatory T cell subsets identifies predictive population signaturesSemantic proximity Read

Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activitySemantic proximity Read