Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RORγt and RORα signature genes in human Th17 cells

1 Aug 2017

Abstract excerpt

RORγt and RORα are transcription factors of the RAR-related orphan nuclear receptor (ROR) family. They are expressed in Th17 cells and have been suggested to play a role in Th17 differentiation. Although RORγt signature genes have been characterized in mouse Th17 cells, detailed information on its transcriptional control in human Th17 cells is limited and even less is known about RORα signature genes which have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma and respiratory diseases
Share to IL-33, ST2, and ILC Pathways
Share to Psoriasis: Treatment and Pathogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28763457
DOI: 10.1371/journal.pone.0181868

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RORγt and RORα signature genes in human Th17 cellsPMID 28763457Read ↗

Genetic and pharmacological inhibition of the nuclear receptor RORα regulates TH17 driven inflammatory disordersSemantic proximity Read ↗

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper CellsSemantic proximity Read ↗

Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivoSemantic proximity Read ↗

Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivoSemantic proximity Read ↗

Retinoic acid receptor-related orphan receptor gamma-t (RORγt) inhibitors in clinical development for the treatment of autoimmune diseases: a patent review (2016-present)Semantic proximity Read ↗

Genes associated with T helper 17 cell differentiation and functionSemantic proximity Read ↗

Transcription Factor Retinoid-Related Orphan Receptor γt: A Promising Target for the Treatment of PsoriasisSemantic proximity Read ↗

NFAT primes the human RORC locus for RORγt expression in CD4+ T cellsSemantic proximity Read ↗

LncRNA STAT4-AS1 inhibited TH17 cells differentiation by targeting RORγt proteinSemantic proximity Read ↗

A two-amino-acid substitution in the transcription factor RORγt disrupts its function in TH17 differentiation but not in thymocyte development.Semantic proximity Read ↗

IRF4 regulates IL-17A promoter activity and controls RORγt-dependent Th17 colitis in vivoSemantic proximity Read ↗

Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.