Article
A single nucleotide polymorphism in the gene for GPR183 increases its surface expression on blood lymphocytes of patients with inflammatory bowel disease.
British journal of pharmacology - 1 Aug 2021
Ruiz Florian, Wyss Annika, Rossel Jean-Benoît, Sulz Michael Christian, Brand Stephan, Moncsek Anja, Mertens Joachim C, Roth René, Clottu Aurélie S, Burri Emanuel, Juillerat Pascal, Biedermann Luc, Greuter Thomas, Rogler Gerhard, Pot Caroline, Misselwitz Benjamin
Abstract excerpt
BACKGROUND AND PURPOSE: Single nucleotide polymorphism rs9557195 within the gene of the G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2/GPR183) has been associated with increased risk for inflammatory bowel diseases (IBD). GPR183 mediates the migration of intestinal immune cells and promotes colitis in animal models. Here, we study GPR183 surface expression of immune cells and associations of...
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