Article

Context-specific regulation of monocyte surface IL7R expression and soluble receptor secretion by a common autoimmune risk allele

2018-02-08

Abstract excerpt

IL-7 is a key factor in T-cell immunity and IL7R polymorphisms are implicated in autoimmune pathogenesis. IL7R mRNA is induced in stimulated monocytes in a genetically determined manner, yet a role for IL7R in monocyte biology remains unexplored. Here we characterize genetic regulation of IL7R at the protein level across multiple cell subsets and conditions in healthy individuals. We find monocyte surface and sol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f7f5fd47-1714-566f-978a-5d01dfbc76c3
DOI: 10.1101/262410

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Context-specific regulation of monocyte surface IL7R expression and soluble receptor secretion by a common autoimmune risk alleleDOI 10.1101/262410Read

Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk alleleSemantic proximity Read

IL7RA haplotype-associated alterations in cellular immune function and gene expression patterns in multiple sclerosis.Semantic proximity Read

IL7RA genetic variants differentially affect IL-7Rα expression and alternative splicing: a role in autoimmune and infectious diseases?Semantic proximity Read

Gene expression and genotyping studies implicate the interleukin 7 receptor in the pathogenesis of primary progressive multiple sclerosis.Semantic proximity Read

Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis.Semantic proximity Read

IRF5 risk polymorphisms contribute to interindividual variance in pattern recognition receptor-mediated cytokine secretion in human monocyte-derived cells.Semantic proximity Read

Variation in IL7R predisposes to sarcoid inflammation.Semantic proximity Read

Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes.Semantic proximity Read

Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis.Semantic proximity Read

CD127 imprints functional heterogeneity to diversify monocyte responses in human inflammatory diseasesSemantic proximity Read

Genetic determinants of cytokine production in activated human monocytesSemantic proximity Read

Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases.Semantic proximity Read