Prognostic significance of FLT3-ITD length in AML patients treated with intensive regimens.

doi:10.1038/s41598-021-00050-x

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Article

Prognostic significance of FLT3-ITD length in AML patients treated with intensive regimens.

Scientific reports - 20 Oct 2021

Castaño-Bonilla Tamara, Alonso-Dominguez Juan M, Barragán Eva, Rodríguez-Veiga Rebeca, Sargas Claudia, Gil Cristina, Chillón Carmen, Vidriales María B, García Raimundo, Martínez-López Joaquín, Ayala Rosa, Larrayoz María J, Anguita Eduardo, Cuello Rebeca, Cantalapiedra Alberto, Carrillo Estrella, Soria-Saldise Elena, Labrador Jorge, Recio Isabel, Algarra Lorenzo, Rodríguez-Medina Carlos, Bilbao-Syeiro Cristina, López-López Juan A, Serrano Josefina, De Cabo Erik, Sayas María J, Olave María T, Sánchez-García Joaquín, Mateos Mamen, Blas Carlos, López-Lorenzo Jose L, Lainez-Gonzalez Daniel, Serrano Juana, Martínez-Cuadrón David, Sanz Miguel A, Montesinos Pau

Abstract excerpt

FLT3-ITD mutations are detected in approximately 25% of newly diagnosed adult acute myeloid leukemia (AML) patients and confer an adverse prognosis. The FLT3-ITD allelic ratio has clear prognostic value. Nevertheless, there are numerous manuscripts with contradictory results regarding the prognostic relevance of the length and insertion site (IS) of the FLT3-ITD fragment. We aimed to assess the prognostic impact...

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Identifiers

PMID: 34671057
DOI: 10.1038/s41598-021-00050-x
PMCID: PMC8528825

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