Article
Impact of numerical variation, allele burden, mutation length and co-occurring mutations on the efficacy of tyrosine kinase inhibitors in newly diagnosed FLT3- mutant acute myeloid leukemia.
Blood cancer journal - 4 May 2020
Abou Dalle Iman, Ghorab Ahmad, Patel Keyur, Wang Xuemei, Hwang Hyunsoo, Cortes Jorge, Issa Ghayas C, Yalniz Fevzi, Sasaki Koji, Chihara Dai, Price Allyson, Kadia Tapan, Pemmaraju Naveen, Daver Naval, DiNardo Courtney, Ravandi Farhad, Kantarjian Hagop M, Borthakur Gautam
Abstract excerpt
FLT3-ITD mutations in newly diagnosed acute myeloid leukemia (AML) are associated with worse overall survival (OS). FLT3-ITD diversity can further influence clinical outcomes. Addition of FLT3 inhibitors to standard chemotherapy has improved OS. The aim of this study is to evaluate the prognostic...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Cytogenetics
- Female
- Humans
- Leukemia, Myeloid, Acute
- Male
- Middle Aged