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Article

Current knowledge about FLT3 gene mutations, exploring the isoforms, and protein importance in AML.

Molecular biology reports - 16 Apr 2024

Macečková Diana, Vaňková Lenka, Holubová Monika, Jindra Pavel, Klieber Robin, Jandová Eliška, Pitule Pavel

Abstract excerpt

Acute myeloid leukaemia (AML) is a complex haematological malignancy characterised by diverse genetic alterations leading to abnormal proliferation of myeloid precursor cells. One of the most significant genetic alterations in AML involves mutations in the FLT3 gene, which plays a critical role in haematopoiesis and haematopoietic homeostasis. This review explores the current understanding of FLT3 gene mutations...

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Identifiers

PMID: 38625438
DOI: 10.1007/s11033-024-09452-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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