Article
Medium-sized FLT3 internal tandem duplications confer worse prognosis than short and long duplications in a non-elderly acute myeloid leukemia cohort.
Leukemia & lymphoma - 1 Jul 2014
Koszarska Magdalena, Meggyesi Nora, Bors Andras, Batai Arpad, Csacsovszki Otto, Lehoczky Eniko, Adam Emma, Kozma Andras, Lovas Nora, Sipos Andrea, Krahling Tunde, Dolgos Janos, Remenyi Peter, Fekete Sandor, Masszi Tamas, Tordai Attila, Andrikovics Hajnalka
Abstract excerpt
Internal tandem duplications (ITDs) of the fms-like tyrosine kinase 3 (FLT3) gene occur in about 25% of patients with adult acute myeloid leukemia (AML). The aim of our study was to investigate the frequency of FLT3-ITD mutations followed by a detailed analysis of the mutational load and size of ITD insertions in a cohort consisting of 324 patients younger than 60 years old and treated with curative intention....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.