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Article

Integrating FLT3-ITD molecular features with clinical risk factors improves risk stratification in acute myeloid leukemia.

Annals of hematology - 15 Jan 2026

Zhang Kainan, Ma Xiaohang, Lu Xiaoxuan, Ruan Guorui, Wei Fangfang, Jiang Hao, Chang Yingjun, Huang Xiaojun, Zhao Xiaosu

Abstract excerpt

This study aimed to investigate the prognostic value of FLT3-ITD molecular features such as allelic ratio (AR), variant allele frequency (VAF), insertion length, insertion number and insertion site in patients with de novo acute myeloid leukemia (AML). Next-generation sequencing (NGS) was used to detect FLT3-ITD mutations in 170 patients with newly diagnosed AML (except acute promyelocytic leukemia). FLT3-ITD...

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Source

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Identifiers

PMID: 41535414
DOI: 10.1007/s00277-026-06802-x
PMCID: PMC12804227

Genes

FLT3
EFS
AR

Provenance

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