Article
Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease.
Blood - 1 Jul 2002
Schnittger Susanne, Schoch Claudia, Dugas Martin, Kern Wolfgang, Staib Peter, Wuchter Christian, Löffler Helmut, Sauerland Cristina Maria, Serve Hubert, Büchner Thomas, Haferlach Torsten, Hiddemann Wolfgang
Abstract excerpt
FLT3 length mutation (FLT3-LM) is a molecular marker potentially useful for the characterization of acute myeloid leukemia (AML). To evaluate the distribution of FLT3-LM within biologic subgroups, we screened 1003 patients with AML at diagnosis for this mutation. FLT3-LM was found in 234 (23.5%) of all patients and thus is the most frequent mutation in AML described so far. Of all positive patients, 165 (70.5%)...
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