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Article

Impact of FLT3-ITD allele ratio and ITD length on therapeutic outcome in cytogenetically normal AML patients without NPM1 mutation.

Bone marrow transplantation - 1 Apr 2020

Chen Fang, Sun Junya, Yin Changxin, Cheng Jiaying, Ni Jinle, Jiang Ling, Wang Qiang, Yu Guopan, Wei Yongqiang, Liu Xiaoli, Sun Jing, Carter Bing Z, Jiang Xuejie

Abstract excerpt

Mutations of internal tandem duplication in FMS-like tyrosine kinase 3 (FLT3-ITD) contribute to poor prognosis in cytogenetically normal acute myeloid leukemia (CN-AML). Chemotherapy has limited effect, while allogeneic hematopoietic stem cell transplantation (allo-HSCT) plus sorafenib maintenance is a promising protocol to improve their therapeutic outcome. However, the prognostic significance of FLT3-ITD mutant...

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PMID: 31645666
DOI: 10.1038/s41409-019-0721-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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