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Article

Impact of FLT3-ITD length on prognosis of acute myeloid leukemia

3 Aug 2018

Abstract excerpt

The FMS-like tyrosine kinase-3 internal tandem duplication (FLT3-ITD) is one of the most frequent mutations found in acute myeloid leukemia (AML) patients, with a frequency of 20-30%. The sizes of ITDs vary dramatically. 1 The FLT3-ITD consists of in-frame insertions of duplicated sequences, most of them (70%) are located in the juxtamembrane domain (JMD), while the remaining are in tyrosine kinase domain 1...

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PMID: 30076182
DOI: 10.3324/haematol.2018.191809

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