Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

OGR1-dependent regulation of the allergen-induced asthma phenotype.

American journal of physiology. Lung cellular and molecular physiology - 1 Dec 2021

Nayak Ajay P, Deshpande Deepak A, Shah Sushrut D, Villalba Dominic R, Yi Roslyn, Wang Nadan, Penn Raymond B

Abstract excerpt

The proton-sensing receptor, ovarian cancer G protein-coupled receptor (OGR1), has been shown to be expressed in airway smooth muscle (ASM) cells and is capable of promoting ASM contraction in response to decreased extracellular pH. OGR1 knockout (OGR1KO) mice are reported to be resistant to the asthma features induced by inhaled allergen. We recently described certain benzodiazepines as OGR1 activators capable...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allergens
Share to Anti-Anxiety Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Asthma

Share to Benzodiazepines

Share to Bronchial Hyperreactivity

Share to Pneumonia

Share to Pyroglyphidae

Share to Receptors, G-Protein-Coupled

Source

Open in PubMed Open full text

Identifiers

PMID: 34668419
DOI: 10.1152/ajplung.00200.2021
PMCID: PMC8715030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

OGR1-dependent regulation of the allergen-induced asthma phenotype.PMID 34668419Read ↗

MyD88 in lung resident cells governs airway inflammatory and pulmonary function responses to organic dust treatment.Semantic proximity Read ↗

Effects of β-blockers on house dust mite-driven murine models pre- and post-development of an asthma phenotype.Semantic proximity Read ↗

House dust mite and Th2 cytokine-mediated epithelial barrier dysfunction attenuation by KL001 in 16-HBE cellsSemantic proximity Read ↗

Guwiyang Wurra--'Fire Mouse': a global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies.Semantic proximity Read ↗

Melatonin modulates airway smooth muscle cell phenotype by targeting the STAT3/Akt/GSK-3β pathway in experimental asthma.Semantic proximity Read ↗

A Novel Quinoline With Airway Relaxant Effects and Anti-Inflammatory PropertiesSemantic proximity Read ↗

The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35.Semantic proximity Read ↗

Modeling the Effects of Cypermethrin Toxicity on Ovalbumin-Induced Allergic Pneumonitis Rats: Macrophage Phenotype Differentiation and p38/STAT6 Signaling Are Candidate Targets of Pirfenidone Treatment.Semantic proximity Read ↗

A novel model of spontaneous otitis media with effusion (OME) in the Oxgr1 knock-out mouse.Semantic proximity Read ↗

Phosphodiesterase 4 Inhibitors Attenuate the Asthma Phenotype Produced by β2-Adrenoceptor Agonists in Phenylethanolamine N-Methyltransferase-Knockout Mice.Semantic proximity Read ↗

β-Blockers have differential effects on the murine asthma phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.