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Article

MyD88 in lung resident cells governs airway inflammatory and pulmonary function responses to organic dust treatment.

Respiratory research - 16 Sept 2015

Poole Jill A, Wyatt Todd A, Romberger Debra J, Staab Elizabeth, Simet Samantha, Reynolds Stephen J, Sisson Joseph H, Kielian Tammy

Abstract excerpt

Inhalation of organic dusts within agriculture environments contributes to the development and/or severity of airway diseases, including asthma and chronic bronchitis. MyD88 KO (knockout) mice are nearly completely protected against the inflammatory and bronchoconstriction effects induced by acute organic dust extract (ODE) treatments. However, the contribution of MyD88 in lung epithelial cell responses remains...

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Identifiers

PMID: 26376975
DOI: 10.1186/s12931-015-0272-9
PMCID: PMC4574163

Genes

CXCL1
CXCL2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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