Article
Effects of β-blockers on house dust mite-driven murine models pre- and post-development of an asthma phenotype.
Pulmonary pharmacology & therapeutics - 1 Oct 2017
Joshi Radhika, Valdez Daniel, Kim Hosu, Eikenburg Douglas C, Knoll Brian J, Bond Richard A
Abstract excerpt
BACKGROUND: Our previous studies suggested certain β-adrenoceptor blockers (β-blockers) attenuate the asthma phenotype in ovalbumin driven murine models of asthma. However, the ovalbumin model has been criticized for lack of clinical relevance. METHODS: We tested the non-selective β-blockers, carvedilol and nadolol, in house dust mite (HDM) driven murine asthma models where drugs were administered both pre- and...
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