Article
Melatonin modulates airway smooth muscle cell phenotype by targeting the STAT3/Akt/GSK-3β pathway in experimental asthma.
Cell and tissue research - 1 Apr 2020
Yu Qijun, Yu Xiaowei, Zhong Xiuhua, Ma Yuan, Wu Yan, Bian Tao, Huang Mao, Zeng Xiaoning
Abstract excerpt
Among the troika of clinicopathologic features of asthma, airway remodelling has gained sufficient attention for its contribution to progressive airway narrowing. Much effort has been directed at the management of airway smooth muscle cells (ASMCs), but few attempts have proven to prevent the progression of remodelling. Recently, accumulating data have shown the anti-inflammatory/anti-proliferative potency of...
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