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Article

β-Blockers have differential effects on the murine asthma phenotype.

British journal of pharmacology - 1 Oct 2015

Thanawala V J, Valdez D J, Joshi R, Forkuo G S, Parra S, Knoll B J, Bouvier M, Leff P, Bond R A

Abstract excerpt

BACKGROUND AND PURPOSE: Our previous studies have shown the β2 -adrenoceptor and its endogenous ligand, adrenaline, are required for development of the asthma phenotype in murine asthma models. Chronic administration of some, but not other, β-blockers attenuated the asthma phenotype and led us to hypothesize that biased signalling was the basis of their differential effects, experimentally and clinically....

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Identifiers

PMID: 26211486
DOI: 10.1111/bph.13253
PMCID: PMC4621987

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PNMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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