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Distinct Mutation Landscapes Between Acute Myeloid Leukemia With Myelodysplasia-Related Changes and De Novo Acute Myeloid Leukemia.

American journal of clinical pathology - 4 May 2022

Gao Yajuan, Jia Mingnan, Mao Yueying, Cai Hao, Jiang Xianyong, Cao Xinxin, Zhou Daobin, Li Jian

Abstract excerpt

OBJECTIVES: To explore the distinct mutation profiles between acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) and de novo AML and their relationships with prognosis. METHODS: Next-generation sequencing of 42 myeloid neoplasm-related genes in 293 newly diagnosed patients with AML. RESULTS: Eighty-four patients had AML-MRC, and 161 patients had de novo AML. The mutation rates of ASXL1 (25% vs...

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PMID: 34664628
DOI: 10.1093/ajcp/aqab172

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