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Mutational profiling of myeloid neoplasms associated genes may aid the diagnosis of acute myeloid leukemia with myelodysplasia-related changes.

Leukemia research - 1 Nov 2021

Yu James, Du Yuan, Jalil Anum, Ahmed Zohaib, Mori Shahram, Patel Rushang, Varela Juan Carlos, Chang Chung-Che

Abstract excerpt

AML with myelodysplasia-related changes (AML-MRC) is a subtype of AML known to have adverse prognosis. The karyotype abnormalities in AML-MRC have been well established; however, relatively little has been known about the role of gene mutation profiles by next generation sequencing. 177 AML patients (72 AML-MRC and 105 non-MRC AML) were analyzed by NGS panel covering 53 AML related genes. AML-MRC showed...

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Identifiers

PMID: 34481124
DOI: 10.1016/j.leukres.2021.106701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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