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Article

MDS/AML and AML with myelodysplasia-related gene mutations: clinical and molecular similarities.

Blood advances - 24 Feb 2026

Boertjes Emma L, Grob Tim, Al Hinai Adil, Beverloo Berna H B, Versluis Jurjen, Kavelaars François G, Rijken Melissa, Compagne Kyra G, Erpelinck Claudia A J, Sanders Mathijs A, Stoetman Elodie C G, Hanekamp Diana, Gradowska Patrycja L, Ossenkoppele Gert J, Biemond Bart J, Manz Markus G, Pabst Thomas, Jongen-Lavrencic Mojca, Löwenberg Bob, Valk Peter J M

Abstract excerpt

ABSTRACT: Acute myeloid leukemia (AML) is driven by diverse genetic abnormalities. We investigated clinical and molecular differences between clinically defined secondary AML following antecedent MDS, molecularly defined secondary type AML (st-AML), molecularly defined MDS/AML (st-MDS/AML; 10%-19% blasts) and other newly diagnosed AML (de novo AML). We also examined the prognostic value of molecular measurable...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41529224
DOI: 10.1182/bloodadvances.2025018408
PMCID: PMC12914417

Genes

ASXL1
BCOR
ETV6
SF3B1
SRSF2
STAG2
U2AF1
ZRSR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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