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Article

Interrogation of molecular profiles can help in differentiating between MDS and AML with MDS-related changes.

Leukemia & lymphoma - 1 Jun 2020

Badar Talha, Szabo Aniko, Sallman David, Komrojki Rami, Lancet Jefferey, Padron Eric, Song Jinming, Hussaini Mohammad Omar

Abstract excerpt

A subset of AML with myelodysplastic syndrome (MDS)-related changes (MRCs) occurs without a documented MDS phase. We studied genomic profile of 646 patients: 310 with MDS, 167 with AML without (w/o) MRC, 99 with primary (p) AML-MRC, and 70 with secondary (s) AML-MRC and sought to find differences in mutational patterns. Among the 32-myeloid associated genes studied, SF3B1 (p ≤ .001) was significantly mutated in...

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RUNX1 gene
SETBP1 gene
SF3B1 gene
SRSF2 gene
Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myelodysplastic Syndromes

Source

Identifiers

PMID: 32013644
DOI: 10.1080/10428194.2020.1719089

Genes

FLT3
NPM1
NRAS
RUNX1
SETBP1
SF3B1
SRSF2
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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