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Whole Exome Sequencing of Intermediate-Risk Acute Myeloid Leukemia without Recurrent Genetic Abnormalities Offers Deeper Insights into New Diagnostic Classifications.

International journal of molecular sciences - 8 Aug 2024

Guijarro Francesca, Castaño-Díez Sandra, Jiménez-Vicente Carlos, Garrote Marta, Álamo José Ramón, Gómez-Hernando Marta, López-Oreja Irene, Morata Jordi, López-Guerra Mònica, López Cristina, Beà Sílvia, Costa Dolors, Colomer Dolors, Díaz-Beyá Marina, Rozman Maria, Esteve Jordi

Abstract excerpt

Two new diagnostic classifications of acute myeloid leukemia (AML) were published in 2022 to update current knowledge on disease biology. In previous 2017-edition categories of AML with myelodysplasia-related changes, AML was not otherwise specified, but AML with mutated RUNX1 experienced profound changes. We performed whole exome sequencing on a cohort of 69 patients with cytogenetic intermediate-risk AML that...

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Core Binding Factor Alpha 2 Subunit
DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Exome Sequencing

Leukemia, Myeloid, Acute

Myelodysplastic Syndromes

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Identifiers

PMID: 39201354
DOI: 10.3390/ijms25168669
PMCID: PMC11354381

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