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Strategies for genetic manipulation of adult stem cell-derived organoids

1 Oct 2021

Abstract excerpt

Organoid technology allows the expansion of primary epithelial cells from normal and diseased tissues, providing a unique model for human (patho)biology. In a three-dimensional environment, adult stem cells self-organize and differentiate to gain tissue-specific features. Accessibility to genetic manipulation enables the investigation of the molecular mechanisms underlying cell fate regulation, cell...

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PMID: 34663937
DOI: 10.1038/s12276-021-00609-8

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