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Article

Drug Discovery via Human-Derived Stem Cell Organoids

22 Sept 2016

Abstract excerpt

Patient-derived cell lines and animal models have proven invaluable for the understanding of human intestinal diseases and for drug development although both inherently comprise disadvantages and caveats. Many genetically determined intestinal diseases occur in specific tissue microenvironments that are not adequately modeled by monolayer cell culture. Likewise, animal models incompletely recapitulate the complex...

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Identifiers

PMID: 27713700
DOI: 10.3389/fphar.2016.00334

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