Article
β-Lactams increase the antibacterial activity of daptomycin against clinical methicillin-resistant Staphylococcus aureus strains and prevent selection of daptomycin-resistant derivatives.
Antimicrobial agents and chemotherapy - 1 Dec 2012
Mehta Shrenik, Singh Christopher, Plata Konrad B, Chanda Palas K, Paul Arundhati, Riosa Sarah, Rosato Roberto R, Rosato Adriana E
Abstract excerpt
Methicillin-resistant Staphylococcus aureus (MRSA) has emerged to be one of the most important pathogens both in health care and in community-onset infections. Daptomycin (DAP) is a cyclic anionic lipopeptide recommended for treatment of skin infections, bacteremia, and right-sided endocarditis caused by MRSA. Resistance to DAP (DAP(r)) has been reported in MRSA and is mostly accompanied by a parallel decrease in...
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