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Article

Restoration of daptomycin sensitivity with adjunctive cefazolin is associated with C-terminal MprF mutations in MRSA bacteremia isolates.

Antimicrobial agents and chemotherapy - 3 Jun 2026

Davis Kathleen P, Poonawala Husain, Murphy Connor, Thorpe Cheleste, Rosato Adriana, Aldridge Bree B

Abstract excerpt

Daptomycin (DAP) or vancomycin (VAN) resistance can result in methicillin-resistant Staphylococcus aureus (MRSA) bacteremia treatment failure. Clinical trials have not yielded a clear approach to MRSA combination therapy. Furthermore, there is not a protocol approved by the Clinical Laboratory Standards Institute (CLSI) for testing most possible antibiotic combinations, and methodology used in basic research...

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PMID: 42037396
DOI: 10.1128/aac.01547-25
PMCID: PMC13231919

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DAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Restoration of daptomycin sensitivity with adjunctive cefazolin is associated with C-terminal MprF mutations in MRSA bacteremia isolates.PMID 42037396Read ↗

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