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Article

Clonal germinal center B cells function as a niche for T-cell lymphoma

3 Aug 2022

Abstract excerpt

Angioimmunoblastic T-cell lymphoma (AITL) is proposed to be initiated by age-related clonal hematopoiesis (ACH) with TET2 mutations, whereas the G17V RHOA mutation in immature cells with TET2 mutations promotes the development of T follicular helper (TFH)-like tumor cells. Here, we investigated the mechanism by which TET2-mutant immune cells enable AITL development using mouse models and human samples. Among the...

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PMID: 35921527
DOI: 10.1182/blood.2022015451

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