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Article

Matrix metalloproteinase-9 inhibition or deletion attenuates portal hypertension in rodents.

Journal of cellular and molecular medicine - 1 Nov 2021

Huang Hui-Chun, Ho Hsin-Ling, Chang Ching-Chih, Chuang Chiao-Lin, Pun Chon Kit, Lee Fa-Yauh, Huang Yi-Hsiang, Hou Ming-Chih, Hsu Shao-Jung

Abstract excerpt

Liver cirrhosis and portal hypertension are accompanied by hyperdynamic circulation, angiogenesis and portosystemic collaterals. Matrix metalloproteinases (MMPs) participate in fibrogenesis and angiogenesis, however, whether they can be targeted in cirrhosis treatment is unclear. Therefore, we performed three series of experiments to investigate this issue. Liver cirrhosis was induced by common bile duct ligation...

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Identifiers

PMID: 34647412
DOI: 10.1111/jcmm.16940
PMCID: PMC8572799

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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