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Article

Involvement of matrix metalloproteinase-2 in the development of renal interstitial fibrosis in mouse obstructive nephropathy.

Laboratory investigation; a journal of technical methods and pathology - 1 Aug 2012

Du Xuanyi, Shimizu Akira, Masuda Yukinari, Kuwahara Naomi, Arai Takashi, Kataoka Mitue, Uchiyama Masaaki, Kaneko Tomohiro, Akimoto Toshio, Iino Yasuhiko, Fukuda Yuh

Abstract excerpt

Renal fibrosis is a common finding in progressive renal diseases. Matrix metalloproteinases (MMPs) are involved in epithelial-to-mesenchymal transition (EMT). We investigated the role of MMP-2 and the effect of inhibition of MMPs on the development of renal fibrosis. Renal fibrosis was induced in MMP-2 wild-type (MMP-2⁺/⁺) mice by unilateral ureteral obstruction (UUO). Renal histopathology, EMT-associated...

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PMID: 22614125
DOI: 10.1038/labinvest.2012.68

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ILK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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