Article
Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans.
Gastroenterology - 1 Jul 2009
Wasmuth Hermann E, Lammert Frank, Zaldivar Mirko Moreno, Weiskirchen Ralf, Hellerbrand Claus, Scholten David, Berres Marie-Luise, Zimmermann Henning, Streetz Konrad L, Tacke Frank, Hillebrandt Sonja, Schmitz Petra, Keppeler Hildegard, Berg Thomas, Dahl Edgar, Gassler Nikolaus, Friedman Scott L, Trautwein Christian
Abstract excerpt
BACKGROUND & AIMS: Fibrosis is the hallmark of chronic liver diseases, yet many aspects of its mechanism remain to be defined. Chemokines are ubiquitous chemotactic molecules that mediate many acute and chronic inflammatory conditions, and CXC chemokine genes colocalize with a locus previously shown to include fibrogenic genes. We investigated the roles of the chemokine CXCL9 and its receptor CXCR3 in liver...
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