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Article

Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jan 2008

Rullier Anne, Gillibert-Duplantier Jennifer, Costet Pierre, Cubel Gaëlle, Haurie Valérie, Petibois Cyril, Taras Danièle, Dugot-Senant Nathalie, Deleris Gérard, Bioulac-Sage Paulette, Rosenbaum Jean

Abstract excerpt

Thrombin inhibition protects against liver fibrosis. However, it is not known whether the thrombin profibrogenic effect is due to effects on blood coagulation or to signaling via protease-activated receptors (PARs). We took advantage of the lack of blood coagulation defects in PAR-1-knockout mice. Acute carbon tetrachloride (CCl(4)) toxicity was similar in wild-type (WT), PAR-1(-/-), and PAR-1(+/-) mice as judged...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17962354
DOI: 10.1152/ajpgi.00444.2007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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