Article
Dynamic features of liver fibrogenesis and fibrosis resolution in the absence of matrix metalloproteinase‑9.
Molecular medicine reports - 1 Dec 2019
Wang Quanrongzi, Liu Xisheng, Zhang Jie, Lu Ling, Feng Min, Wang Jie
Abstract excerpt
The two‑edged effect of matrix metalloproteinase‑9 (MMP9) makes it difficult to understand its role in liver fibrogenesis and fibrosis resolution. The present study aimed to investigate the dynamic features of liver fibrogenesis and fibrosis resolution in the absence of MMP9. MMP9‑/‑ mice were used to induce liver fibrosis by thioacetamide. The degrees of liver fibrogenesis and fibrosis resolution were designated...
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