Article

MKK4 knockdown plays a protective role in haemorrhagic shock-induced liver injury through the JNK pathway

2022-04-08

Abstract excerpt

<title>Abstract</title> <p>Haemorrhagic shock (HS) triggers tissue hypoxia and organ failure during severe blood loss, and the liver is sensitive to HS. Mitogen-activated protein kinase kinase 4 (MKK4) activates the c-Jun NH2-terminal kinase (JNK) pathway, and its expression is upregulated in the serum of HS patients and mouse livers at 1 h post-HS. However, the function of MKK4 in HS-induced liver injury is uncl...

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Literature Corpus work: 9b004d25-53b5-53ef-8edf-cd6f56828038
DOI: 10.21203/rs.3.rs-1491667/v1

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