Article
Association of functional gene polymorphisms of matrix metalloproteinase (MMP)-1, MMP-3 and MMP-9 with the progression of chronic liver disease.
Journal of gastroenterology and hepatology - 1 Jul 2005
Okamoto Kinya, Mimura Kenichi, Murawaki Yoshikazu, Yuasa Isao
Abstract excerpt
BACKGROUND AND AIMS: Matrix metalloproteinases (MMP) play an important role in the progression of liver fibrosis in addition to fibrogenesis. MMP-1, MMP-3, and MMP-9 gene polymorphisms have been shown to influence the transcriptional activity of their respective gene promoter in an allele-specific manner. The aim of this study was to examine the possible association of MMP-1, MMP-3, and MMP-9 gene polymorphisms...
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