Article
Liver-specific overexpression of matrix metalloproteinase 9 (MMP-9) in transgenic mice accelerates development of hepatocellular carcinoma.
Molecular carcinogenesis - 1 Jun 2012
Thieringer Florian R, Maass Thorsten, Anthon Bianca, Meyer Erik, Schirmacher Peter, Longerich Thomas, Galle Peter R, Kanzler Stephan, Teufel Andreas
Abstract excerpt
Matrix metalloproteinase-9 (MMP-9) plays a central role in tumor invasion and development of metastases. Expression of MMP-9 had been shown in human hepatocellular carcinomas (HCCs). However, it remained unclear whether MMP-9 could influence development of HCC. In order to address this issue, we generated transgenic mice overexpressing MMP-9 in the liver. In order to avoid embryonic lethality a Cre-lox system was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.