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Article

Mutant MMP-9 and HGF gene transfer enhance resolution of CCl4-induced liver fibrosis in rats: role of ASH1 and EZH2 methyltransferases repression.

PloS one - 1 Jan 2014

Atta Hussein, El-Rehany Mahmoud, Hammam Olfat, Abdel-Ghany Hend, Ramzy Maggie, Roderfeld Martin, Roeb Elke, Al-Hendy Ayman, Raheim Salama Abdel, Allam Hatem, Marey Heba

Abstract excerpt

UNLABELLED: Hepatocyte growth factor (HGF) gene transfer inhibits liver fibrosis by regulating aberrant cellular functions, while mutant matrix metalloproteinase-9 (mMMP-9) enhances matrix degradation by neutralizing the elevated tissue inhibitor of metalloproteinase-1 (TIMP-1). It was shown that ASH1 and EZH2 methyltransferases are involved in development of liver fibrosis; however, their role in the resolution...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25380300
DOI: 10.1371/journal.pone.0112384
PMCID: PMC4224431

Genes

HGF
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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