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FOXA1 of regulatory variant associated with risk of breast cancer through allele-specific enhancer in the Chinese population.

Breast cancer (Tokyo, Japan) - 1 Mar 2022

Li Bin, Cheng Xiang, Zhu Ying, Wan Hao, Lu Zequn, Cai Yimin, Li Wenhui, Yi Pengfei, Liu Li, Chang Jiang, Miao Xiaoping, Tian Jianbo, Zhong Rong

Abstract excerpt

BACKGROUND: FOXA1 is a pioneer transcription factor which has been established as a carcinogenic factor and can regulate the expression of downstream target genes in breast cancer. We hypothesized that genetic variants modulating FOXA1 expression might play a role in the risk of breast cancer. METHODS: Physical interaction predicted by PreSTIGE analysis and CHIA-PET data integration with cis-expression...

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PMID: 34635981
DOI: 10.1007/s12282-021-01305-1

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